We're going to troubleshoot issues together until the resolution is found or we run out of options. I'm going to dive in to the nastiest problems that you hope you never have, and try to resolve them so that we can all just play our game already.
If you've been playing the game for months or years and have dozens of mods loaded and you ran into a problem where it locks up or crashes, this guide may be able to help you. If you just bought the game, and it won't run, this guide may be able to help you. Well I'm bringing to this guide, knowledge that I've gained in fixing Fallout 4 problems, in the hopes that someone searches the guides for help and manages to find it here. People post new threads with titles like 'help! my fallout won't load' or 'fallout crashes to desktop when.', and I would jump right in to those threads and try to help find a resolution to the problem.
The gnarliest threads were my favorite ones to dive in to. I spent months in the Fallout 4 forum helping people to get their Fallout 4 game running.